Thymosin alpha 1 immune-enhancing peptide

What's Thymosin alpha 1?

Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. 

Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells. 




Adverse Effects and Contraindications:

Thymalfasin, the synthetic form of thymosin alpha 1, is usually well tolerated. The most common adverse effects include local irritation, redness, or discomfort at the site of injection. In clinical trials, the combination of thymalfasin with interferon 2b was reported to have rare side effects such as fever, fatigue, muscle aches, nausea, vomiting, and neutropenia when compared to interferon-alpha 2b alone or with placebo. Thymalfasin is contraindicated in patients with hypersensitivity to thymosin alpha 1 or any of the components of the injection. Due to the immunomodulatory action of thymalfasin, it is also contraindicated in immu-nosuppressed patients, such as organ transplant recipients, unless the benefits of the treatment exceed the risks.


Dosage of Thymosin:

Thymosin alpha 1 is usually found in an injection form and is commonly prescribed by a primary care physician. Thymosin alpha 1 is usually administered twice a week via a subcutaneous route. The standard single dosage ranges from 0.8 to 6.4 mg, while multiple doses range from 1.6 to 16 mg for five to seven days. Utilized in various illnesses such as liver disease, cancer, and autoimmune diseases, thymosin alpha 1 has been shown to be well-tolerated and safe


Storage of  Thymosin alpha 1:

Thymosin alpha 1 should be stored at -20 degrees Celsius. Lyophilized thymosin alpha 1 may remain stable for up to three weeks at room temperature; however, for long term storage, it should be kept below -180 degrees Celsius and stored in the desiccated form. When ready to use, it may be reconstituted and subsequently stored at 40 degrees Celsius for a period of two to seven days. If the intention is to store thymosin alpha 1 for a longer period of time, then it is advised to store it in combination with a carrier protein such as 0.1% human serum albumin or bovine serum albumin. It is recommended to avoid repeated freezing and thawing.







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